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1

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity

Rekha G. Panchal, St. Patrick Reid, Julie P. Tran, Alison A. Bergeron, Jay Wells, Krishna P. Kota, Javad Aman, Sina Bavari

Journal:

Antiviral Research

Year:

2012

Language:

english

File:

PDF, 791 KB

english, 2012

2

Analysis of Ebola virus and VLP release using an immunocapture assay

George Kallstrom, Kelly L. Warfield, Dana L. Swenson, Shannon Mort, Rekha G. Panchal, Gordon Ruthel, Sina Bavari, M. Javad Aman

Journal:

Journal of Virological Methods

Year:

2005

Language:

english

File:

PDF, 421 KB

english, 2005

3

Applications ofIn VivoImaging in the Evaluation of the Pathophysiology of Viral and Bacterial Infections and in Development of Countermeasures to BSL3/4 Pathogens

Bocan, Thomas M., Panchal, Rekha G., Bavari, Sina

Journal:

Molecular Imaging and Biology

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

4

Functional Reconstitution of Protein Ion Channels into Planar Polymerizable Phospholipid Membranes

Shenoy, Devanand K., Barger, William R., Singh, Alok, Panchal, Rekha G., Misakian, Martin, Stanford, Vincent M., Kasianowicz, John J.

Journal:

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

5

A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor

Selaković, Života, Opsenica, Dejan, Eaton, Brett, Retterer, Cary, Bavari, Sina, Burnett, James C., Šolaja, Bogdan A., Panchal, Rekha G.

Journal:

Year:

2012

Language:

english

File:

PDF, 688 KB

english, 2012

6

High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection

Kota, Krishna P., Benko, Jacqueline G., Mudhasani, Rajini, Retterer, Cary, Tran, Julie P., Bavari, Sina, Panchal, Rekha G.

Journal:

Year:

2012

Language:

english

File:

PDF, 598 KB

english, 2012

7

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

Iversen, Patrick, Warren, Travis, Wells, Jay, Garza, Nicole, Mourich, Dan, Welch, Lisa, Panchal, Rekha, Bavari, Sina

Journal:

Year:

2012

Language:

english

File:

PDF, 422 KB

english, 2012

8

Shedding Light on Filovirus Infection with High-Content Imaging

Pegoraro, Gianluca, Bavari, Sina, Panchal, Rekha G.

Journal:

Year:

2012

Language:

english

File:

PDF, 440 KB

english, 2012

9

Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding

James C. Burnett, James J. Schmidt, Connor F. McGrath, Tam L. Nguyen, Ann R. Hermone, Rekha G. Panchal, Jonathan L. Vennerstrom, Krishna Kodukula, Daniel W. Zaharevitz, Rick Gussio, Sina Bavari

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 919 KB

english, 2005

10

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR

Timothy J. Opperman, John D. Williams, Chad Houseweart, Rekha G. Panchal, Sina Bavari, Norton P. Peet, Donald T. Moir, Terry L. Bowlin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 488 KB

english, 2010

11

Chemical Genetic Screening Identifies Critical Pathways in Anthrax Lethal Toxin-Induced Pathogenesis

Rekha G. Panchal, Gordon Ruthel, Katherine C. Brittingham, Douglas Lane, Tara A. Kenny, Rick Gussio, John S. Lazo, Sina Bavari

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

12

A theoretical study of anthrax lethal factor inhibition by a set of novel carbamimidolyl-aryl-vinyl-carboxamidines: A possible mechanism involving zinc-ligation by amidine

Tam Luong Nguyen, Rekha G. Panchal, Igor A. Topol, Douglas Lane, Tara Kenny, James C. Burnett, Ann R. Hermone, Connor McGrath, Stanley K. Burt, Rick Gussio, Sina Bavari

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

2007

Language:

english

File:

PDF, 497 KB

english, 2007

13

Genetically Targeted Calcium Sensors Enhance The Study Of Organelle Function In Living Cells

Steven Petrou, David N Bowser, Robert A Nicholls, Rekha G Panchal, Megan L Smart, Angela M Reilly, David A Williams

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2000

Language:

english

File:

PDF, 347 KB

english, 2000

14

Proceedings of the Australian Physiological and Pharmacological Society Symposium: New Frontiers in Muscle Research Gene transfer: manipulating and monitoring function in cells and tissues

Rekha G Panchal, David A Williams, Peter D Kitchener, Angela M Reilly, Jameel Khan, David N Bowser, Steven Petrou

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2001

Language:

english

File:

PDF, 255 KB

english, 2001

15

Erratum to: “Molecular mechanisms of filovirus cellular trafficking” [Microbes Infect. 5 (2003) 639–649]

M.Javad Aman, Catharine M. Bosio, Rekha G. Panchal, James C. Burnett, Alan Schmaljohn, Sina Bavari

Journal:

Microbes and Infection

Year:

2003

Language:

english

File:

PDF, 91 KB

english, 2003

16

Oncogene Amplification in Squamous Cell Carcinoma of the Oral Cavity

Dhananjaya Saranath, Rekha G. Panchal, Rama Nair, Ashok R. Mehta, Vikram Sanghavi, Janos Sumegi, George Klein, Madhav G. Deo

Journal:

Year:

1989

File:

PDF, 448 KB

1989

17

Tumor protease-activated, pore-forming toxins from a combinatorial library

Panchal, Rekha G., Cusack, Evelyn, Cheley, Stephen, Bayley, Hagan

Journal:

Nature Biotechnology

Year:

1996

File:

PDF, 893 KB

1996

18

Mutant GABAA receptor γ2-subunit in childhood absence epilepsy and febrile seizures

Wallace, Robyn H., Marini, Carla, Petrou, Steven, Harkin, Louise A., Bowser, David N., Panchal, Rekha G., Williams, David A., Sutherland, Grant R., Mulley, John C., Scheffer, Ingrid E.

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

19

Identification of small molecule inhibitors of anthrax lethal factor

Panchal, Rekha G, Hermone, Ann R, Nguyen, Tam Luong, Wong, Thiang Yian, Schwarzenbacher, Robert, Schmidt, James, Lane, Douglas, McGrath, Connor, Turk, Benjamin E, Burnett, James

Journal:

Nature Structural and Molecular Biology

Year:

2003

Language:

english

File:

PDF, 354 KB

english, 2003

20

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells

Heltemes, Lynn M, Hagan, Christy R, Mitrofanova, Elena E, Panchal, Rekha G, Guo, Jun, Link, Charles J

Journal:

Cancer Gene Therapy

Year:

2003

Language:

english

File:

PDF, 307 KB

english, 2003

21

A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

Burnett, James C., Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G., Ruthel, Gordon, Hermone, Ann R., Nguyen, Tam L., Kenny, Tara A., Lane, Douglas J., McGrath, Connor F.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 317 KB

english, 2007

22

Combinatorial RNA splicing alters the surface charge on the NMDA receptor

Vellareddy Anantharam, Rekha G. Panchal, Andrew Wilson, Vladimir V. Kolchine, Steven N. Treistman, Hagan Bayley

Journal:

Year:

1992

Language:

english

File:

PDF, 474 KB

english, 1992

23

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity

James C Burnett, James J Schmidt, Robert G Stafford, Rekha G Panchal, Tam L Nguyen, Ann R Hermone, Jonathan L Vennerstrom, Connor F McGrath, Douglas J Lane, Edward A Sausville, Daniel W Zaharevitz, Ri

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 383 KB

english, 2003

24

Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection

Rekha G. Panchal, Steven B. Bradfute, Brian D. Peyser, Kelly L. Warfield, Gordon Ruthel, Douglas Lane, Tara A. Kenny, Arthur O. Anderson, William C. Raschke, Sina Bavari

Journal:

Cell Host & Microbe

Year:

2009

Language:

english

File:

PDF, 2.02 MB

english, 2009

25

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: Structural insights into the monomer–hexamer transition

Tam Luong Nguyen, Guy Schoehn, Winfried Weissenhorn, Ann R. Hermone, James C. Burnett, Rekha G. Panchal, Connor McGrath, Dan W. Zaharevitz, M. Javad Aman, Rick Gussio, Sina Bavari

Journal:

Journal of Structural Biology

Year:

2005

Language:

english

File:

PDF, 1.50 MB

english, 2005

26

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

John E. Herrmann, Shixia Wang, Chuanyou Zhang, Rekha G. Panchal, Sina Bavari, C. Rick Lyons, Julie A. Lovchik, Basil Golding, Joseph Shiloach, Shan Lu

Journal:

Year:

2006

Language:

english

File:

PDF, 387 KB

english, 2006

27

Molecular mechanisms of filovirus cellular trafficking

M.Javad Aman, Catharine M Bosio, Rekha G Panchal, James C Burnett, Alan Schmaljohn, Sina Bavari

Journal:

Microbes and Infection

Year:

2003

Language:

english

File:

PDF, 332 KB

english, 2003

28

Novel Therapeutic Strategies to Selectively Kill Cancer Cells

Rekha G Panchal

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 304 KB

english, 1998

29

Sizing the Bacillus anthracis PA63 Channel with Nonelectrolyte Poly(Ethylene Glycols)

Nablo, Brian J., Halverson, Kelly M., Robertson, Joseph W.F., Nguyen, Tam L., Panchal, Rekha G., Gussio, Rick, Bavari, Sina, Krasilnikov, Oleg V., Kasianowicz, John J.

Journal:

Biophysical Journal

Year:

2008

Language:

english

File:

PDF, 381 KB

english, 2008

30

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Warren, Travis K., Wells, Jay, Panchal, Rekha G., Stuthman, Kelly S., Garza, Nicole L., Van Tongeren, Sean A., Dong, Lian, Retterer, Cary J., Eaton, Brett P., Pegoraro, Gianluca, Honnold, Shelley, Ban

Journal:

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

31

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: Synthesis and SAR of novel analogs of MBX 1066 and MBX 1090

Williams, John D., Nguyen, Son T., Gu, Shen, Ding, Xiaoyuan, Butler, Michelle M., Tashjian, Tommy F., Opperman, Timothy J., Panchal, Rekha G., Bavari, Sina, Peet, Norton P., Moir, Donald T., Bowlin, T

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 5.73 MB

english, 2013

32

Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer

Saranath, Dhananjaya, Panchal, Rekha G, Nair, Rama, Mehta, Ashok R, Sanghavi, Vikram D, Deo, Madhav G

Journal:

European Journal of Cancer Part B: Oral Oncology

Year:

1992

Language:

english

File:

PDF, 726 KB

english, 1992

33

A high-content imaging assay for the quantification of theBurkholderia pseudomalleiinduced multinucleated giant cell (MNGC) phenotype in murine macrophages

Pegoraro, Gianluca, Eaton, Brett P, Ulrich, Ricky L, Lane, Douglas J, Ojeda, Jenifer F, Bavari, Sina, DeShazer, David, Panchal, Rekha G

Journal:

BMC Microbiology

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

34

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds

Nguyen, Son T., Williams, John D., Butler, Michelle M., Ding, Xiaoyuan, Mills, Debra M., Tashjian, Tommy F., Panchal, Rekha G., Weir, Susan K., Moon, Chaeho, Kim, Hwa-Ok, Marsden, Jeremiah A., Peet, N

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1017 KB

english, 2014

35

Caged Catalytic Subunit of cAMP-Dependent Protein Kinase

Chang, Chung-yu, Fernandez, Tania, Panchal, Rekha, Bayley, Hagan

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 38 KB

english, 1998

36

Anthrax toxin-induced rupture of artificial lipid bilayer membranes

Nablo, Brian J., Panchal, Rekha G., Bavari, Sina, Nguyen, Tam L., Gussio, Rick, Ribot, Wil, Friedlander, Art, Chabot, Donald, Reiner, Joseph E., Robertson, Joseph W. F., Balijepalli, Arvind, Halverson

Journal:

The Journal of Chemical Physics

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

37

Partial Functional Correction of Xeroderma Pigmentosum Group A Cells by Suppressor tRNA

Panchal, Rekha G., Wang, Suming, Mcdermott, Jeffrey, Link, Charles J.

Journal:

Human Gene Therapy

Year:

1999

Language:

english

File:

PDF, 745 KB

english, 1999

38

Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery

Panchal, Rekha G., Mourich, Dan V., Bradfute, Steven, Hauck, Laura L., Warfield, Kelly L., Iversen, Patrick L., Bavari, Sina

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2014

Language:

english

File:

PDF, 471 KB

english, 2014

39

[IEEE 2008 66th Annual Device Research Conference (DRC) - Santa Barbara, CA, USA (2008.06.23-2008.06.25)] 2008 Device Research Conference - Electronic Detection of Biomolecules

Kasianowicz, John J., Robertson, Joseph W.F., Reiner, Joseph E., Nablo, Brian J., Krasilnikov, Oleg V., Rodrigues, Claudio M., Panchal, Rekha M., Nguyen, Tam L., Gussio, Rick, Bavari, Sina, Halverson,

Year:

2008

Language:

english

File:

PDF, 4.14 MB

english, 2008

40

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis

Panchal, Rekha G, Lane, Douglas, Boshoff, Helena I, Butler, Michelle M, Moir, Donald T, Bowlin, Terry L, Bavari, Sina

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 239 KB

english, 2013

41

Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Kiris, Erkan, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Peyser, Brian D., Du, Hao T., Gomba, Glenn Y., Kota, Krishna P., Panchal, Rekha G., Gussio, Rick, Kane, Christopher D., Tessarollo

Journal:

Neurotoxicity Research

Year:

2015

Language:

english

File:

PDF, 5.04 MB

english, 2015

42

Anti-Ebola Activity of Diazachrysene Small Molecules

Selaković, Života, Soloveva, Veronica, Gharaibeh, Dima N., Wells, Jay, Šegan, Sandra, Panchal, Rekha G., Šolaja, Bogdan A.

Journal:

ACS Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

43

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

Cazares, Lisa H, Van Tongeren, Sean A, Costantino, Julie, Kenny, Tara, Garza, Nicole L, Donnelly, Ginger, Lane, Douglas, Panchal, Rekha G, Bavari, Sina

Journal:

BMC Microbiology

Year:

2015

Language:

english

File:

PDF, 1.65 MB

english, 2015

44

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

Madrid, Peter B., Panchal, Rekha G., Warren, Travis K., Shurtleff, Amy C., Endsley, Aaron N., Green, Carol E., Kolokoltsov, Andrey, Davey, Robert, Manger, Ian D., Gilfillan, Lynne, Bavari, Sina, Tanga

Journal:

ACS Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

45

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways

Alem, Farhang, Yao, Kuan, Lane, Douglas, Calvert, Valerie, Petricoin, Emanuel F., Kramer, Liana, Hale, Martha L., Bavari, Sina, Panchal, Rekha G., Hakami, Ramin M.

Journal:

Frontiers in Microbiology

Year:

2015

Language:

english

File:

PDF, 3.46 MB

english, 2015

46

Filovirus‐Like Particles Produced in Insect Cells: Immunogenicity and Protection in Rodents

Warfield, Kelly L., Posten, Nichole A., Swenson, Dana L., Olinger, Gene G., Esposito, Dominic, Gillette, William K., Hopkins, Ralph F., Costantino, Julie, Panchal, Rekha G., Hartley, James L., Aman, M

Journal:

The Journal of Infectious Diseases

Year:

2007

Language:

english

File:

PDF, 386 KB

english, 2007

47

10.1038/88259

Wallace, Robyn H., Marini, Carla, Petrou, Steven, Harkin, Louise A., Bowser, David N., Panchal, Rekha G., Williams, David A., Sutherland, Grant R., Mulley, John C., Scheffer, Ingrid E., Berkovic, Samu

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

48

[WORLD SCIENTIFIC Proceedings of the Pacific Symposium - Kohala Coast, Hawaii, USA (3 – 7 January 2013)] Biocomputing 2013 - PREDICTIVE SYSTEMS BIOLOGY APPROACH TO BROAD-SPECTRUM, HOST-DIRECTED DRUG TARGET DISCOVERY IN INFECTIOUS DISEASES

FELCIANO, RAMON M., BAVARI, SINA, RICHARDS, DANIEL R., BILLAUD, JEAN-NOEL, WARREN, TRAVIS, PANCHAL, REKHA, KRÄMER, ANDREAS

Language:

english

File:

PDF, 1.50 MB

english

49

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Taylor, Raymond, Kotian, Pravin, Warren, Travis, Panchal, Rekha, Bavari, Sina, Julander, Justin, Dobo, Sylvia, Rose, Angela, El-Kattan, Yahya, Taubenheim, Brian, Babu, Yarlagadda, Sheridan, William P.

Journal:

Journal of Infection and Public Health

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

50

Bacterial genome engineering and synthetic biology: combating pathogens

Krishnamurthy, Malathy, Moore, Richard T., Rajamani, Sathish, Panchal, Rekha G.

Journal:

BMC Microbiology

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016